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Journal Publications Manelli AM, Bulfinch L, Sullivan PM, and MJ LaDu. Effect of Aβ structure and human apoE isoform on primary co-cultures of neurons and glia. Neurobiol. of Aging. 28:1139-1147, 2007.
Yun SY, Gamkredlidze G, Stine B, Sullivan PM, Pasternak JF, LaDu MJ, and B Trommer. Amyloid-β-42 reduces neuronal excitability in mouse dentate gyrus. Neuroscience Letters. 403(1-2):162-165 2006.
LaDu MJ, Stine WB, Narita M, Getz GS, Reardon CA, and G Bu. Self-assembly of HEK cell-secreted apoE particles resemble apoE-enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry. 45:381-390, 2006.
Rebeck, G.W., LaDu M.J., Estus, S., Bu, G., and E.J. Weeber. The generation and function of soluble apoE receptors in the CNS. Mol. Neurodegener. 1:1-13, 2006.
Yun SH, Park KA, Sullivan P, Pasternak JF, LaDu MJ, and BL Trommer. ACh receptors supress hippocampal LTP in wild type but not apoE4 targeted replacement mice . J. Neurosci. Res. 82(6):771-777, 2005.
Chen S, Averett NT, Manelli AM, LaDu MJ, May W, and MD Ard. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia . J. of Alzheimer's Disease. 7(1):25-35, 2005.
White JA, Manelli AM, Holmberg KH, Van Eldik LJ, and MJ LaDu. Differential effects of oligomeric and fibrillar amyloid-β1-42 on glia-mediated inflammation. Neurobiol. Dis. 18(3):459-465, 2005.
Trommer BL, Shah C, Gamkrelidze G, Yun SH, Pasternak ES, Stine B, Manelli A, Sullivan P, Pasternak JF, and MJ LaDu. Apolipoprotein E isoform-specific effects on LTP: blockade by oligomeric amyloid-β. Neurobiol. Dis. 18(1):75-82, 2005.
Trommer BL, Shah C, Gamkrelidze G, Yun SH, Pasternak ES, Ye G, Sotak M, Sullivan P, Pasternak JF, and MJ LaDu. Apolipoprotein E isoform affects LTP in human targeted-replacement mice. Neuroreport. 15 (17):2655-2658, 2004.
Irizarry M, Deng A, Lleo A, Berezovska O, von Armin C, Martin-Rehrmann M, Manelli A, LaDu MJ , Hyman B, and GW Rebeck E.S. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J. Neurochem. 23:235-246, 2004.
Guo L, LaDu MJ, and LJ Van Eldik. A dual role for apolipoprotein E in neuroinflammation: anti- and pro-inflammatory activity. J. Mol. Neuroscience. 23:203-210, 2004.
Manelli AM, Stine Jr., Van Eldik LJ, and MJ LaDu. ApoE and Aβ1-42 interactions: effects of isoform and conformation on structure and function. J. Mol. Neurosci. 23(3):235-46, Review, 2004.
Stine Jr., Dahlgren KD, Krafft GA, and MJ LaDu. In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis. J. Biol. Chem. 278(13):11612-22, 2003.
Dahlgren KD, Manelli AM, Stine Jr. WB, Baker LK, Krafft GA, and MJ LaDu. Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J. Biol. Chem. 277(35):32046-53, 2002.
Narita M, Holtzman DM, Fagan AM, LaDu MJ, Yu L, Han X, Gross RW, Bu G, and AL Schwartz. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. J. Biochem. 132:743-749, 2002.
Bentley NB, LaDu MJ, Rajan C, Getz GS, and CA Reardon. ApoE structural requirements for SDS-stable complex formation with β-amyloid (1-40). Biochemical J. 366:273-279, 2002.
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses. Neurochem. Int. 39(5-6):427-34, Review, 2001.
Munson GW, Roher AE, Kuo YM, Gilligan SM, Reardon CA, Getz GS, and MJ LaDu. SDS-stable complex formation between native apolipoprotein E3 and β-amyloid peptides. Biochemistry 26;39(51):16119-24, 2000.
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures. J. Biol. Chem. 27;275(43):33974-80, 2000.
Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith J, LaDu MJ, Rostagno A, Frangione B, and J Ghiso. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β-peptide. Biochem. J. 348:359-365, Review, 2000.
Fagan AM, Holtzman DM, Munson G, Mathur T, Schneider D, Chang LK, Getz GS, Reardon CA, Lukens J, Shah JA, and MJ LaDu. Unique lipoproteins secreted by primary astrocytes from wild type, apoE null and human apoE transgenic mice. J. Biol. Chem. 15;274(42):30001-7, 1999.
Hu J, LaDu MJ, and LJ Van Eldik. Apolipoprotein E attenuates β-amyloid astrocyte activation. J. Neurochem. 71:1626-1634, 1998.
LaDu MJ, Gilligan S, Lukens JR, Cabana V, Reardon CA, Van Eldik LJ, and DM Holtzman. CSF lipoproteins differ from nascent astrocyte particles. J. Neurochem. 70(5):2070-2081, 1998.
Sun Y, Fagan A, Wu S, Onifade K, Patel S, LaDu MJ, Bu G, and DM Holtzman. GFAP-apoE transgenic mice: Astrocyte-specific expression and differing biologic effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J. Neurosci. 18(9):3261-3272, 1998.
Jordan J, Galindo MF, Miller RJ, Reardon CA, Getz GS, and MJ LaDu. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid induced toxicity in rat hippocampal pyramidal neuronal cultures. J. Neurosci. 18(1):195-204, 1998.
LaDu MJ, Lukens JR, Reardon CA, and GS Getz. Association of human, rat, and rabbit apolipoprotein E with β-amyloid. J. Neurosci. Res. 49(1):9-18, 1997.
Puttfarcken PS, Manelli AM, Falduto MT, Getz GS and MJ LaDu. Effects of apolipoprotein E on neurite outgrowth and β-amyloid induced toxicity in developing rat primary hippocampal cultures. J. Neurochem. 68(2):760-769, 1997.
Metzger RE, LaDu MJ, Frail DE, Pan JB, Getz GS, and MT Falduto. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J. Neuropath. Exp. Neurol. 55:372-380, 1996.
LaDu MJ, Pederson TM, Frail DE, Reardon CA, Getz GS, and MT Falduto. Purification of apolipoprotein E attenuates isoform-specific binding to β-amyloid. J. Biol. Chem. 270:9039-9042, 1995.
LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, and DE Frail. Isoform-specific binding of apolipoprotein E to β-amyloid. J. Biol. Chem. 269:23403-23406, 1994.
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