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Related Publications Manelli, A.M., Stine Jr., W.B., Van Eldik, L.J., and M.J. Ladu. ApoE and Aβ1-42 interactions: effects of isoform and conformation on structure and function. J Mol Neurosci. 23:235-246, Review, 2004.
Rebeck, G.W., Kindy, M., and M.J. LaDu. Apolipoprotein E and Alzheimer's disease: the protective effect of apoE2 and E3. J Alzheimers Dis. 4(6):145-154, Review, 2002.
Trommer, B.L., Shah, C., Gamkrelidze, G., Yun, S.H., Pasternak, E.S., Ye, G., Sotak, M., Sullivan, P., Pasternak, J.F., and M.J. LaDu. Apolipoprotein E isoform affects LTP in human targeted-replacement mice. Neuroreport 15(17):2655-2658, 2004.
Metzger, R.E., LaDu, M.J., Frail, D.E., Pan, J.B., Getz, G.S., and M.T. Falduto. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J Neuropath Exp Neurol. 55:372-380, 1996.
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ApoE and the Brain ApoE staining of neurons in normal brain  [Mahley, Science, 1988] Figure 1a. ApoE staining of plaques and tangles in AD brain.
 [Mahley, Science, 1988] Figure 1b.  [Metzger, J. Neuropath, 1996] Figure 1c. Glial staining (brown) in normal and AD brains. ApoE staining of amyloid plaques (blue) in AD brain, surrounded by inflamed glia. ApoE and ApoE Receptors in the Brain  Figure 2. Although apoE is synthesized by glial cells, it is a secretory protein that is taken up by both neurons and glia via apoE receptors. Role of ApoE in PNS Injury  [Mahley, Science, 1988] Figure 3. Related publications: Manelli, A.M., Stine Jr., W.B., Van Eldik, L.J., and M.J. Ladu. ApoE and Aβ1-42 interactions: effects of isoform and conformation on structure and function. J Mol Neurosci. 23:235-246, Review, 2004.
Rebeck, G.W., Kindy, M., and M.J. LaDu. Apolipoprotein E and Alzheimer's disease: the protective effect of apoE2 and E3. J Alzheimers Dis. 4(6):145-154, Review, 2002.
Trommer, B.L., Shah, C., Gamkrelidze, G., Yun, S.H., Pasternak, E.S., Ye, G., Sotak, M., Sullivan, P., Pasternak, J.F., and M.J. LaDu. Apolipoprotein E isoform affects LTP in human targeted-replacement mice. Neuroreport 15(17):2655-2658, 2004.
Metzger, R.E., LaDu, M.J., Frail, D.E., Pan, J.B., Getz, G.S., and M.T. Falduto. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J Neuropath Exp Neurol. 55:372-380, 1996.
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