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Related Publications Chen S, Averett NT, Manelli AM, LaDu MJ, May W, and MD Ard. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. J. of Alzheimer's Disease. 7(1):25-35, 2005.
LaDu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, and GS Getz. Lipoproteins in the central nervous system. Ann N Y Acad Sci. 903:167-75. Review, 2000.
Fagan AM, Holtzman DM, Munson G, Mathur T, Schneider D, Chang LK, Getz GS, Reardon CA, Lukens J, Shah JA, and MJ LaDu. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem. 274(42):30001-7, 1999.
LaDu, M.J., Gilligan, S.M., Lukens, J.R., Cabana, V.G., Reardon, C.A., Van Eldik, L.J., and D.M. Holtzman. CSF lipoproteins differ from nascent astrocyte particles. J Neurochem. 70(5):2070-2081, 1998.
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Characterization of CNS Lipoproteins Characterization of CNS lipoproteins, including those found in the CSF and nascent, apoE-containing particles secreted by glial cells by electron microscopy (Figure 1) and size exclusion chromatography (SEC, Figure 2). SEC of Human Plasma  Figure 1. SEC of CNS Lipoproteins  [LaDu, J. Neurochem, 1998] Figure 2. Aβ co-elutes withe CSF and glial lipoproteins analyzed by SEC (Figure 3). SEC profile for human plasma included as a reference (Figure 4). SEC of CNS Lipoproteins and Aβ  Figure 3. CNS Lipoproteins Analyzed by Electron Microscopy  [LaDu, J. Neurochem, 1998] Figure 4. Common Sources of ApoE  [Attribution: Katie Youmans] Figure 5. Related Publications Chen S, Averett NT, Manelli AM, LaDu MJ, May W, and MD Ard. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. J. of Alzheimer's Disease. 7(1):25-35, 2005.
LaDu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, and GS Getz. Lipoproteins in the central nervous system. Ann N Y Acad Sci. 903:167-75. Review, 2000.
Fagan AM, Holtzman DM, Munson G, Mathur T, Schneider D, Chang LK, Getz GS, Reardon CA, Lukens J, Shah JA, and MJ LaDu. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem. 274(42):30001-7, 1999.
LaDu, M.J., Gilligan, S.M., Lukens, J.R., Cabana, V.G., Reardon, C.A., Van Eldik, L.J., and D.M. Holtzman. CSF lipoproteins differ from nascent astrocyte particles. J Neurochem. 70(5):2070-2081, 1998.
Higher Affinity Than ApoE4 Structure/Function of Aβ1-42 Assemblies >> |
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