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Related Publications Rebeck, G.W., Kindy, M., and M.J. LaDu. Apolipoprotein E and Alzheimer's disease: the protective effect of apoE2 and E3. J Alzheimers Dis. 4(6):145-154, Review, 2002.
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses. Neurochem Internat. 39:427-434, Review, 2001.
LaDu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, and GS Getz. Lipoproteins in the central nervous system. Ann N Y Acad Sci. 903:167-75, Review, 2000. abstract | pdf LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures. J Biol Chem. 275(43):33974-80, 2000.
Jordan J, Galindo MF, Miller RJ, Reardon CA, Getz GS, and MJ LaDu. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. J Neurosci. 18(1):195-204, 1998.
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Effects of ApoE that Modify Actions of Aβ are Mediated by ApoE Receptors For additional information on ApoE Receptors, please visit http://apoereceptors.anat.uic.edu/. The effects of apoE in modifying the actions of Aβ in both neurons (Figure 1) and glia (Firgure 2) require apoE receptors, suggesting a clearance and/or signaling mechanism that involves both apoE and Aβ (Figure 3). ApoE Receptors Mediate ApoE4/Aβ Toxicity:
 [Attribution: CJ Yu, Yuangui Zhu] Figure 1. Hypothesis for the Role of ApoE in:
 Figure 2. Mechanism: Effects of ApoE on the Fate of Amyloid-β in the CNS  [LaDu, ANYAS, 2000] Figure 3.Astrocytes secrete nascent lipoproteins with apoE as the primary apolipoprotein. ApoE participates in intercellular lipid transport in the CNS, and may also interact with Aβ to affect fibril formation and amyloid deposition (1) and bind a soluble active form of Aβ, facilitating its clearance (2). Aβ not associated with lipoproteins induces neurotoxicity (3) and inflames glia (4). These processes may also be further modulated by apoE. Related Publications Rebeck, G.W., Kindy, M., and M.J. LaDu. Apolipoprotein E and Alzheimer's disease: the protective effect of apoE2 and E3. J Alzheimers Dis. 4(6):145-154, Review, 2002.
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E and apolipoprotein E receptors modulate Aβ-induced glial neuroinflammatory responses. Neurochem Internat. 39:427-434, Review, 2001.
LaDu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, and GS Getz. Lipoproteins in the central nervous system. Ann N Y Acad Sci. 903:167-75, Review, 2000.
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, and LJ van Eldik. Apolipoprotein E receptors mediate the effects of β-amyloid on astrocyte cultures. J Biol Chem. 275(43):33974-80, 2000.
Jordan J, Galindo MF, Miller RJ, Reardon CA, Getz GS, and MJ LaDu. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures. J Neurosci. 18(1):195-204, 1998.
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