Introduction

ApoE and the Brain

Native ApoE3 Binds Aβ with Higher Affinity than ApoE4

Characterization of CNS Lipoproteins

Structure and Function of Aβ1-42 Assemblies

Aβ-induced Neurotoxicity is Enhanced by ApoE4

Effects of ApoE that Modify Actions of Aβ are Mediated by ApoE Receptors

Metabolism of ApoE3 and E4 ± Aβ-42

Transgenic Mouse Models





Metabolism of ApoE3 and E4 ± Aβ-42


ApoE but not ApoE3 Induces:
Intraneuronal Aβ-42 Accumulation

[Attribution: CJ Yu, Yuangui Zhu]

Figure 1.



ApoE Receptors Mediate the Uptake of both ApoE4 and Aβ-42

[Attribution: CJ Yu, Yuangui Zhu]

Figure 2.



Glial-apoE4 Preferentially Localizes to Recycling Endosomes

[Attribution: Yuangui Zhu]

Figure 3.



Metabolism of ApoE3 and E4 ± Aβ-42

[Attribution: Lisa Jungbauer]

Figure 4.


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