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Transgenic Mouse Models Figure 1. ApoE targeted replacement (apoE-TR) Human apoE is expressed by glia in a conformation and at physiological levels in a temporal and spatial pattern comparable to endogenous mouse apoE. [Sullivan, 2004] Reduced Synaptophysin Staining in ApoE4-TR (CA3)  [Attribution: Lindsey Bulfinch] Figure 1. Figure 2. Mice co-expressing five FAD mutations (5xFAD) overproduce almost exclusively human Aβ-42, and show accelerated Aβ deposition both intraneuronally and as extracellular plaques. [Oakley, 2006] Intraneuronal Aβ Immunoreactivity in 5xFAD mouse at 2 months  [Attribution: Yuangui Zhu] Figure 2. Figures 3-5. 5xFAD/apoE-TR crosses neurons constitutively release Aβ-42, the source of Aβ-42 overproduction in AD, and the endogenous mouse apoE promoter regulates the expression of the human apoE isoforms. Reduced Synaptophysin Staining in ApoE4-TR (CA3)  Figure 3. IHC Analysis:
 [Attribution: Yuangui Zhu, Kevin Laxton] Figure 4. << Metabolism of ApoE3 and E4 ± Aβ-42 |
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